ABSTRACT
Authentic texts describe Grudhrasi under Vata Roga. One of its main clinical features is a pain that radiates from Sphik Pradesha (buttocks) to Pada (foot). It can be corelated with sciatica. Piyusharnava, describes that Parisheka Sweda using Nauclea orientalis (Bakmi) as a treatment for Katigaha (Lumbago). Vasti Karma using N. orientalis (Bakmi) is in practice and Vasti is the best treatment for Vata Roga. Seventy-five patients suffering from Grudhrasi (sciatica) were treated with Parisheka Sweda, Vasti and combined therapy. Parisheka Sweda was carried out for a period of seven days. Vasti was performed as Yoga Vasti. Both therapies were carried out in combined therapy group; namely, Parisheka Sweda followed by Yoga Vasti. All three groups showed statistically significant reduction in all the symptoms but there was no statistical difference between groups. Parisheka Sweda and Yoga Vasti using Nauclea orientalis (Bakmi) can be recommended as an effective treatment for Grudhrasi (sciatica).
ABSTRACT
This study examined the oral anti-inflammatory potential of aqueous extract of Thespesia populnea Linn bark. Soland. Ex. Corr. (Family: Malvaceae) which is used by Sri Lankan native practitioners to treat skin ailments and arthritis. This was tested in conscious male Wistar rats using carrageenan induced paw edema model and three oral doses; 1250, 2500 and 5000mg/kg. Indomethacin was used as the reference drug. The result showed that the aqueous extract of bark significantly P<0.05 and dose dependently inhibited both early (1-2 h) and late phase (4-5 h) of inflammation in the carrageenan model. In addition, it inhibited the intermediated phase (3 h). The anti-inflammatory activity of the highest doses of extract was comparable to that of indomethacin. The extract did not display overt signs of toxicity and was neither hepatotoxic, renotoxic nor hematotoxic even with chronic administration. It is concluded that aqueous bark extract of Thespesia populnea can function as an orally active, safe and potent anti-inflammatory agent.
ABSTRACT
The aim of the present study was to investigate whether Alpinia calcarata Roscoe (Family: Zingiberaceae) rhizomes have any toxic effects in rats. Wistar rats were used as the experimental model and orally administered hot water extract (HWE) and hot ethanolic extract (HEE) of A. calcarata rhizomes at a dose of 1500 mg/kg respectively for 42 consecutive days. Administration of the HWE or HEE to rats did not result in any chronic toxic effects as evident from their effects on (a) liver function (b) kidney function, (c) hematological parameters such as red blood cell (RBC) count, white blood cell (WBC) count and hemoglobin (Hb) concentration (d) external morphology and wet weights of selected organs. Further, the HWE and the HEE did not appear to mediate any unacceptable effects on food and water intake, percent weight gain, consistency of faeces and color of urine. In conclusion, the results of this study have revealed that the HWE and the HEE of A. calcarata at the doses tested do not produce any serious toxic side effects in rats.
El objetivo del presente estudio fue investigar si los rizomas de Alpinia calcarata Roscoe (Familia: Zingiberaceae) tienen algún efecto tóxico en las ratas. Se utilizaron ratas Wistar como modelo experimental y administrado por vía oral de extracto de agua caliente (EAC) y el extracto de etanol caliente (EEC) de A. rizomas calcarata a una dosis de 1500 mg / kg, respectivamente, durante 42 días consecutivos. La administración de la EAC o EEC a las ratas no produjo ningún efecto crónico tóxico como se desprende de sus efectos sobre la (a) función hepática (b) la función renal, (c) los parámetros hematológicos, como conteo de los glóbulos rojos (GR), conteo de glóbulos blancos celular (GB) y hemoglobina (Hb), (d) morfología externa y el peso húmedo de los órganos seleccionados. Además, el EAC y el EEC no parecen mediar efectos inaceptables en la ingesta de alimentos y agua, porcentaje de aumento de peso, la consistencia de las heces y el color de la orina. En conclusión, los resultados de este estudio han revelado que los extractos EAC y la EEC de A. calcarata en las dosis utilizadas no producen graves efectos secundarios tóxicos en ratas.